Description

• Montelukast (Leukotriene Receptor Antagonist):

1. Inhibits LTD4 Actions: Blocks the effects of LTD4 at the CysT1 receptor.
2. Prevents Smooth Muscle Contraction: Reduces muscle contraction and decreases the secretion of thick, viscous mucus.

• Levocetirizine (Histamine H1R Antagonist):

1. First-Line Agent: Effectively alleviates primary symptoms of allergic rhinitis (AR) such as nasal swelling and congestion.
2. High Affinity: Exhibits a higher affinity for the histamine H1 receptor compared to Cetirizine or Dextrocetirizine.

• Combination Therapy:

1. Relieves Symptoms: Effective for allergic rhinitis, whether seasonal or perennial.
2. Prophylaxis: Used as preventative treatment for seasonal allergic rhinitis.
3. Treats Co-Morbid Conditions: Addresses both asthma and allergic rhinitis in patients aged 15 years and older.

• Indications:

1. Sneezing
2. Nasal Swelling
3. Runny Nose Due to Allergies